Nicolau's syndrome following diclofenac administration: A report of two cases.

(w ww .m ed kn ow .co m) . shoes and to the inner surface of the sandal strap of the third volunteer. The pieces were left in place for one week during which period, the volunteers used the shoes routinely. A small piece of leather 1 x 1 cm in size was removed after one week from each of the six pieces and subjected to spot testing with DPC. Of these six pieces of leather, all the leather pieces soaked in distilled water tested positive, two pieces of leather soaked in vitamin C were negative, but one piece showed a weakly positive, purplish discoloration. Our study proves that freshly prepared vitamin C solution is capable of making leather hypo-allergenic by converting the hexavalent chromium to trivalent chromium. The weekly hexavalent chromium-positive reaction seen in one piece could be due to the leaching effect of sweat from shoes into the vitamin C-treated leather.